ExosomeDx
Exosomes, Oncosomes and Virosomes
Table: Characteristics and applications of cfDNA and exosomes.
![ExosomeDx](https://www.therawis.com/wp-content/uploads/2022/04/ExosomeDx-1024x443.png)
*Quantification of methylation in cfDNA challenging because DNA present from healthy cells may falsify results
**Note: Plasma cfDNA concentration analysis showed more than 93% of amplifiable cfDNA in plasma is located in plasma exosomes (Fernando et al. 2017)
Exosomes should mirror the phenotype of the parent cell, e.g. from the cell they were released. Exosomes secreted from virus-infected cells, called virosomes, have the potential not only to serve to diagnose the virus type but also the cell population or organ which the virus has infected. Similarly, oncosomes, exosomes released from cancer cells, also should mirror the phenotype of the parental cancer cells. Therefore, identification of oncosomes and characterization of the composition could serve as liquid biopsy for cancer therapy, diagnosis and monitoring.
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